Research Technician I

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The Arimura Lab (Basic Sciences Division, Fred Hutch) was just launched in February 2024. We are currently looking for Research Technicians to help establish a diverse, innovative, and collaborative research team.

 

The mission of the Arimura Lab is to achieve the structural elucidation of biological events occurring in eukaryotic chromosomes, such as the transcription regulation in euchromatin and heterochromatin, the mitosis-specific mechanisms that compact chromosomes and assemble kinetochores, and the accessible chromatin formation around transcription start site. Our Lab will accomplish this elucidation by developing novel approaches. The lab currently possesses unique technology to determine the high-resolution cryo-EM structures of chromatin-related complexes isolated from interphase and M phase chromosomes formed in Xenopus (frog) egg extract (PMID: 34478647) and Magnetic Isolation and Concentration (MagIC)-cryo-EM, a technique enabling direct structural analysis of targets captured on nanomagnetic beads, which allows for the structural determination of scarce macromolecules (< 0.0005 mg/mL: 100 to 1000-fold lower than conventional cryo-EM) in heterogeneous samples (PMID: 38328033 [preprint]). By using these unique technologies and further developing them, we elucidate the structural basis of the biological events on eukaryotic chromosomes.

 

Through participation in these research projects, the Research Technician will obtain skills and knowledge in structural biology, chromatin biology, epigenetics, biochemistry, and molecular biology.

• Perform experiments at the bench level to support investigative work.
• Prepare and maintain laboratory reagents, stocks, cultures or cell lines.
• Perform and modify documented protocols and assays.
• Maintain laboratory records and compile data on experiments and assays.
• Interpret and report on experimental results.
• Perform statistical analysis of test results and prepare written reports on work performed.
• Operate and carry out basic maintenance of laboratory equipment.
• Order and maintain appropriate levels of supplies.
• Perform other duties as required.

Research (70~80%): The primary function of the Research Technician will be to carry out research projects under the guidance of the PI or a Postdoctoral Fellow.

 

Lab management (20~30%): Ordering scientific lab supplies, maintaining shared stocks and equipment, and shipping samples help ensure the lab establishes and runs smoothly.

 

Expectations

• Possess self-motivation and excitement about chromatin biology and epigenetics.
• Participate actively in lab meetings, including presenting your own data.
• Perform experiments and/or do experimental analysis for most of each workday.
• Continue learning through independent and guided reading on relevant topics for the project.
• Maintain a strong lab notebook and communicate experimental plans/issues.
• Show respect to all members of the lab and the broader Hutch community.

Minimum Qualifications

 

• A Bachelor’s Degree and research experience in Biochemistry, Biophysics, Biology, or a related discipline in a laboratory environment.

Preferred Qualifications

• An interest in curiosity-driven biological research.
• A willingness to learn and grow as a scientist.
• A willingness to interact with all levels of staff and contribute positively to the lab environment.

Please include a CV and a one-page cover letter that includes the following information:

• Why are you interested in this position?
• What do you hope to learn from this job?
• Why do you think you would be a good candidate for the position?
• What are your long and short-term career goals (including your ideal time frame for the next stages in your career)?

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

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The hourly pay range for this position is from $22.21 to $31.61 and pay offered will be based on experience and qualifications.  

Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, tuition reimbursement, paid vacation (12-22 days per year), paid sick leave (12-25 days per year), paid holidays (13 days per year), paid parental leave (up to 4 weeks), and partially paid sabbatical leave (up to 6 months). 

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to Human Resources at hrops@fredhutch.org or by calling 206-667-4700.