Research Technician III-IV

Job ID
23080
Type
Regular Full-Time
Location
US-WA-Seattle
Category
Laboratory Research Sciences

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures for the world’s deadliest diseases and make life beyond cancer a reality.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

 

This position involves working with investigators pursuing the development, and clinical translation, of innovative immunotherapy-based approaches to treat multiple myeloma and other hematologic malignancies. The environment is supportive, team oriented, and exciting. The successful applicant will be involved in experiments supporting pre-clinical and clinical projects. The specific assays to be performed include the processing of patient tissue specimens obtained from clinical protocols, validation assays on preclinical and cGMP grade clinical agents (radiolabeled monoclonal antibodies), and mouse models of radioimmunotherapy. There is also the opportunity to apply advanced cellular and molecular biology techniques (e.g., single cell RNA sequencing) to evaluate patient responses after receiving treatment with chimeric antigen receptor T-cell therapy. 

Responsibilities

  • Perform various mouse specific procedures (including IP, IV, subQ, RO injections; RO bleeding, oral gavage, cardiac puncture and tissue harvest).
  • Process patient tissue specimens (blood, bone marrow) for sample storage.
  • Coordinate with the clinical team to ensure that patient samples are collected and processed; troubleshoot and address issues as needed.
  • Radiolabel antibodies with radioisotopes including Iodine-125, Iodine-131, Indium-111, Yttrium-90, Astatine-211 and others.
  • Operate a variety of analytical instruments such as gamma counters, dose calibrators, flow cytometers, spectrophotometers.
  • Keep detailed records of experiments conducted.
  • Prepare and present written or oral progress reports concerning studies including assembly, organization, and interpretation of data.
  • Identify methodological problems in research protocols and implement modifications to optimize experimental results.
  • Conduct literature reviews to assist in identifying new methods to be used in research.
  • Employ cellular and molecular biology techniques including ELISA’s, DNA/RNA isolation, sequencing, PCR, RT-PCR, single cell RNA sequencing.
  • Perform other laboratory duties as assigned by supervisor.

Qualifications

  • BS in related scientific field (minimum), Advanced degree/training preferred
  • Superior organization and communication skills
  • Must have experience working with mice or the willingness to be trained in how to perform mouse specific procedures (including IP, IV, subQ, RO injections, RO bleeds, oral gavage, cardiac puncture and tissue harvest.
  • Extensive flow cytometry experience
  • Database skills (REDCap experience a plus)
  • Experience with assay validation and optimization
  • Molecular tissue culture, DNA/RNA isolation, sequencing and molecular analysis experience preferred
  • Experience/familiarity with R and R Studio viewed favorably

 

In addition to job duties at Fred Hutch, this position also requires access to Seattle Cancer Care Alliance, which requires COVID-19 vaccination without exceptions.
Accordingly, as a condition of employment for this Fred Hutch position, newly hired employees must provide proof of vaccination before their first day of employment.

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Our Commitment to Diversity

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at hrops@fredhutch.org or by calling 206-667-4700.

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