Associate Director, HVTN/CoVPN Laboratory Research

Job ID
Regular Full-Time
Fred Hutchinson Cancer Research Center
Laboratory Research Sciences


Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   


The HIV Vaccine Trials Network (HVTN) and Coronavirus Prevention Network (CoVPN) Laboratory in the Immunology & Vaccine Development Program of the Vaccine & Infectious Disease Division is dedicated to understanding human immunology and mechanisms of vaccine-induced immune protection against HIV and other infectious diseases.


This position is a supervisory role for a good clinical laboratory practices (GCLP) compliant laboratory primarily evaluating cellular immune responses to HIV, SARS-CoV-2, malaria, and tuberculosis infections and vaccines.  Responsibilities include directing complex studies, hiring, supervising and mentoring personnel, and maintaining an internationally recognized, GCLP-compliant laboratory of currently up to 15 personnel, including direct and indirect reports. This individual will plan and direct the development, validation and execution of assays to examine vaccine immunity and support product advancement (such as in go/no-go decisions).  The Associate Director will also direct exploratory research projects to answer in-depth immunological questions related to these infectious diseases and the vaccine modalities, with a special emphasis on B and T cell immunology and biomarkers. They will collaborate with internal and external stakeholders including HVTN/CoVPN leadership, academic scientists, clinical trial stakeholders, funders and industry partners. 



  • Reporting to the HVTN LC PI/SVP of the Vaccine & Infectious Disease Division, develop, direct and execute studies of T and B cell responses induced by diverse vaccine modalities and infections (e.g. HIV, SARS-CoV-2, HPV, P. falciparum, and Mtb) under investigation with a focus on Endpoint analyses and assay development, including but not limited to:
    • Provide day-to-day scientific and organizational leadership for the laboratory (up to 15 reports)
      • This includes two staff scientists that have direct reports
    • Mentor and develop talent, provide performance feedback and training opportunities
    • Oversee development and execution of GCLP and R&D cellular immune assays including but not limited to multiparameter flow cytometry, antigen-specific B cell phenotyping, intracellular cytokine staining, IFN-g ELISpot, Luminex/MSD, B-cell ELISpot, B/T cell sorting and sequencing, viral inhibition, and other assays as relevant
    • Lead the establishment of new technologies and assays in the lab
    • Prepare and review data packages for identification of biomarkers and support go/no-go decisions for clinical product advancement
    • Prepare and present data at internal and external meetings and conferences
    • Prepare scientific articles, grant applications and progress reports
    • Identify ways to improve quality and increase capacity and efficiency of the work, including process improvements, communication, equipment, staff management and number of staff
  • Interface with collaborating researchers:
    • Lead scientific projects that collaborate with the HVTN LC and related research programs, including but not limited to the CHAVDs, BMGF CAVD, HIPC, ID-CRC, and VIMC
    • Participate in both formal and informal sharing of data amongst collaborating researchers
    • Interact with statistical collaborators, conducting analyses
  • Participates as a member of the HVTN/CoVPN leadership:
    • Provide immunological expertise in development of new clinical vaccine trials
    • Develop and participate in HVTN processes to develop new clinical trial protocols
    • Coordinate and implement specimen collection and analyses within the HVTN
    • Prepare and present data at meetings and annual HVTN/CoVPN conferences
  • Business development activities and interactions with industry partners:
    • Draft and/or review budgets, scopes of work, and contracts, for collaborations with industry sponsors/collaborators, such as IAVI, J&J, Sanofi Pasteur, Moderna, etc.
  • Maintain communications with external and industry sponsors including establishing and participating in regular teleconferences and correspondence regarding study plans, data transfer plans and packages, and other deliverables
  • Oversee development and iteration of validation experiments, approach and documentation for submission of a drug master file (DMF), including interactions with consultants and regulatory agencies, such as FDA
  • Prepare data analysis, supporting documentation and development of patent applications in conjunction with the Business Development group at the Fred Hutch


  • The ideal candidate will have a M.D. or Ph.D. in Immunology, or a related field, with at least 7 years of postdoctoral research experience in vaccines and human immunology
  • 3-5 years of supervisory and leadership experience with direct reports, including hiring, performance evaluation, and coaching/mentoring.       
  • Expertise in human clinical trial development and implementation, GCLP/GXP regulatory compliance, high-dimensional multiparameter flow cytometry analysis, B and T cell human immunology and multiplex cytokine assays
  • A strong background in collaborative team leadership and project completion is preferred, with the ability to create and manage project schedules, including tasks, deliverables, milestones and schedules
  • Motivation and adaptability are essential, as is a keen interest in the vaccine field
  • Proficiency in the following computer programs is necessary:  MS Office, Illustrator or other drawing program, Prism or other graphing program, JMP and or SAS statistical analysis program, and FlowJo or other flow data analysis program
  • The ability to travel up to 10% of the time domestically and/or internationally to represent the laboratory at meetings and conferences, as required
  • Hours:  Must be flexible, able to work some nights and weekends
  • Special qualifications: willingness to work with biohazardous (e.g., HIV-1) materials
  • Preferred qualifications include exceptional organization, written and oral communication skills, ability to oversee multiple tasks with attention to detail, a motivated/enthusiastic work style, and the ability to work in a fast-paced environment with a broad range of internal and external constituents

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment. 


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Our Commitment to Diversity

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at or by calling 206-667-4700.


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