Post-Doctoral Research Fellow - Targeted Protein Degradation – Nabet lab

Job ID
20699
Type
Regular Full-Time
Location
US-WA-Seattle
Category
Post-Doctoral Research Fellows and Associates

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.


Dr. Behnam Nabet’s laboratory is recruiting a highly motivated postdoctoral fellow to carry out research in the fields of targeted protein degradation and proximity-induced therapeutics. The goals of our research program are to develop strategies to target cancer drivers by controlling protein homeostasis to gain new biological insights into clinically relevant targets and to advance new therapeutic strategies in cancer. The Nabet lab develops and deploys innovative chemical biology technologies such as the dTAG system to rapidly eliminate target proteins for therapeutic target discovery and validation (Nabet et al., Nature Chemical Biology 2018, Ferguson and Nabet et al., Nature Chemical Biology 2020, Nabet et al., Nature Communications 2020). We are committed to supporting the next-generation of scientists and believe in collaborative science (Nabet, ChemBioChem2021). This is an exceptional opportunity to join a new team with a committed mentor that is pushing the boundaries of cancer chemical biology.

Responsibilities

The successful applicant will drive rigorous scientific projects utilizing state-of-the-art targeted degradation approaches including the dTAG system, chemical probes, genome-wide CRISPR knockout screens, molecular biology, biochemistry, next-generation sequencing, and in vivo murine modeling, with the goal of understanding the mechanisms of oncogenes in cancer and developing new therapeutic approaches. The position will require both independent research as well as the ability to collaborate closely with medicinal chemists, computational biologists, and other colleagues.

Qualifications

Essential skills and requirements

We are looking for exceptional candidates with a recent PhD, and/or MD and a track record of independent productive research. Excellent written and verbal communication skills are required. A strong foundation in cell culture, genetic engineering, next-generation sequencing, murine modeling, molecular biology, biochemistry, and/or chemical biology is highly desirable. Fellowship opportunities are available through several philanthropic and government organizations and recruits who join the lab will be supported in their applications.

 

Application instructions

Please apply by submitting a CV, a brief description of past research experiences and future goals (not more than 1-2 pages) and contact information for three references.

 

 

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.

As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment. 

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Our Commitment to Diversity

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at hrops@fredhutch.org or by calling 206-667-4700.

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