Research Technician I/II - Johnston Lab

Job ID
Regular Full-Time
Fred Hutchinson Cancer Research Center
Laboratory Research Sciences


Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   


Research Technician I/II: Molecular Microbiology/Epigenetic Engineering of Prokaryotes/Eukaryotes—Johnston Lab

The Johnston Laboratory within the Vaccine and Infectious Disease Division, is an interdisciplinary and highly collaborative team of microbiologists, synthetic microbiologists, bioinformaticians and engineers. We focus on microbial epigenetics and the application of synthetic biology approaches to understand and engineer the human microbiota. Using cutting edge technologies and methodologies, we seek to gain a deeper functional understanding of what bacteria are doing and how they are doing it, and then to use that information to create novel therapeutics and engineer the next generation of microbe-based technologies for application in human medicine, synthetic microbiology and bioengineering.


We are recruiting a highly motivated research technician with strong expertise in microbiology/molecular biology/genetic engineering of prokaryotes or eukaryotes to join our cutting-edge genomics/epigenomics efforts.


The research technician will be given the opportunity and be responsible for conducting independent and creative research related to the overall mission of the laboratory, specifically relating to design/construction/validation and testing of a suite of novel CRISPR-dCas9-effector systems.


  • Work with the PI, post-doctoral fellows and incumbent technicians using state-of-the-art sequencing technologies and innovative synthetic microbiology, genomics
  • Acquire cutting-edge skills in PacBio Single Molecule Real-time SMRT-Seq platforms, synthetic microbiology research, research planning and strategy, and data analysis and interpretation.
  • Maintain an in-depth understanding of the field in which they are working, and working with the PI, as well as independently, on the planning, design, execution, trouble-shooting, and interpretation of experiments
  • Make detailed observations, record data and present results
  • Assist post docs and fellows in the day-to-day activities
  • Interpret experiments related to assigned projects



  • Research Tech I level: Bachelor's degree is required.
  • Research Tech II level: Bachelor's degree with 4 years’ experience in research/life sciences setting
  • A working knowledge and minimum 2 years’ experience with standard molecular biology and microbiology techniques (nucleic acid isolation/manipulation/PCR/cloning/recombineering transformation, protein isolation/purification) is required.
  • Prior experience in the epigenomic editing, DNA methylation analyses, or the design/construction/application of CRISPR-Cas/dCas effectors in the context of eukaryote or prokaryote research would be a significant advantage.
  • Prior experience with DNA sequencing-based technologies (Illumina/PacBio/Oxford Nanopore) would be useful, though not explicitly required.
  • Prior experience and working knowledge of scientific programs/scripting for analysis of DNA sequencing data would be useful, though not explicitly required.



  • Highly motivated individual interested in a career in biological research or medicine, with a keen interest molecular biology/synthetic biology.
  • Technically meticulous when conducting experiments
  • Highly organized in record-keeping
  • Independent, intellectually passionate and able to display scientific initiative
  • Excellent teamwork, time management and organizational skills
  • Ability to work independently in a dynamic and results-oriented environment
  • Ability to meet deadlines and multitask efficiently is a must

*Please include a cover letter with your application, detailing your suitability and interests for this position



Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment. 


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Our Commitment to Diversity

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at or by calling 206-667-4700.


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