Post-Doctoral Research Fellow, HIV Vaccine Design & Testing

Job ID
Regular Full-Time
Fred Hutchinson Cancer Research Center
Post-Doctoral Research Fellows and Associates


Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   


The McGuire Lab is seeking outstanding postdoctoral fellows to work on a project involving the validating and testing of novel vaccine candidates to elicit broadly neutralizing antibodies against HIV-1.  Responsibilities include: 

  • Design and execute prime-boost immunization regimens in a humanized murine model which will serve as a surrogate for human vaccine trials 
  • Perform endpoint analyses including antigen-specific B cell sorting and serum antibody binding and neutralization assays to gain a high-resolution understanding of the immune response to immunization. 
  • To complement this analysis the candidate will perform single B cell sorting of human PBMC samples ascertain the identity of antigen-reactive naive B cells.  
  • May be required to help with SARS-CoV-2 work as needed 


  • PhD in immunology, biochemistry, or a related field is required and expertise in B cell immunology is highly desirable
  • Experience with conducting in vitro studies with human peripheral blood samples preferred.
  • The candidate should have a strong molecular biology background as well.
  • Experience in multicolor flow cytometry preferred.
  • The candidate must be independent, show initiative, willingness to take up new skills and responsibilities, and be a team player
  • Excellent attention to detail and the ability to work independently are essential to success in this position, as are good communication and organizational skills
  • The candidate must be self-motivated, able to multitask and to work within a very collaborative environment

Our Commitment to Diversity

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer.  We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected.  We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class.  We are an Affirmative Action employer.  We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our HR Operations at or by calling 206-667-4700.


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