Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The post-doctoral research fellow will work on independent and collaborative projects developing adoptive T cell immunotherapy for hematologic and solid tumor malignancies within the Program in Immunology and Clinical Research Division at Fred Hutch. The successful applicant will employ strategies for cloning T cell receptors and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The research fellow will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy. The Program in Immunology is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. The post-doctoral research fellow may also participate in the laboratory evaluation of ongoing clinical trials involving engineering of peripheral blood stem cell grafts for improved allogeneic hematopoietic stem cell transplantation outcomes, and in the development of future immunotherapy strategies.
The post-doctoral research fellow will work on independent and collaborative projects within the Program in Immunology at Fred Hutch as part of our Clinical Research Division studying the function of human T cells. The position will involve molecular work with PCR, cloning, vector design, as well as, cell culture, cell sorting, flow cytometry, intercellular staining, transfections, ELISPOT and Chromium Release Assays.
Applicants will have a MD and/or a PhD in a biological science. The ideal candidate will have a strong research background with robust skills in molecular biology and cellular immunology, including experience in designing cloning strategies, flow cytometry and cell signaling based assays.
Experience in analysis of T Cell Receptor (TCR) signaling pathways and in lentiviral modification of T cells will be an advantage.
To be successful in this position, the post-doctoral research fellow must be highly motivated and driven to establish a career as a future independent investigator.