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The Bernstein Lab is recruiting a technician II/III to engage in studies of the role of the Notch pathway in hematopoiesis and in T cell development.
The research in the Bernstein lab has primarily focused on developmental aspects of normal and leukemic hematopoiesis with the specific goal of developing novel therapeutic modalities. In these efforts we have identified maturation linked cell surface antigens and have utilized this information for developing methods for targeted therapy of hematologic malignancies and for isolating and characterizing normal and malignant human hematopoietic stem cells. Current studies of normal hematopoiesis are aimed at determining the role of the Notch pathway to direct primitive hematopoietic precursors to commit to a particular maturational pathway or to self-renew. These efforts are currently being extended in studies of CAR T-cell self renewal and differentiation. Recent studies of leukemia focus on how cells in the marrow microenvironment protect the leukemic stem cells from therapy.
Experience with flow cytometry essential and a broad range of standard molecular biology techniques is preferred
Research Technician II - A bachelor’s degree in biological science and research experience beyond course work are absolutely essential. The candidate should have at least two years of full-time, post-bachelor's laboratory experience.
Research Technician III - As Research Technician II but with five or more years of full-time post-bachelor's laboratory experience.