Research Technician II/III, Image Analysis

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Immunopathology Lab in the Clinical Research Division is seeking a well-organized and highly motivated Research Technician to join the Multiplex Immunohistochemistry (mIHC) Team with a focus on image acquisition and analysis. The Lab utilizes cutting-edge technologies in a Team Science approach to interrogate the tumor microenvironment through tissue-based analyses of immunotherapy clinical and pre-clinical trials. Determination of Technician II vs III will be based on experience.

• Acquire images of brightfield and fluorescence immunohistochemistry, to include 7 or more markers, on a variety of scanning microscopes
• Carry out image analyses of brightfield, standard fluorescence, and multiplex immunohistochemistry images including spatial analysis
• Work with bioinformatics collaborators to maximize data throughput and interpretation
• Act as a digital pathology resource for collaborators
• Perform immunohistochemistry and immunofluorescence on automated platforms
• Maintain sample and reagent inventories
• Make buffers and aliquot reagents
• Maintain laboratory records and compile data on experiments and assays in shared databases
• Provide methods, images, and data for analysis reports, grant applications, manuscripts, and posters
• Participate in weekly lab meetings

Requirements:

• BA/BS in biology, immunology, or related field or digital pathology experience (2+ years)
• Expertise in image analysis software, such as Definiens or Indica Labs’ HALO (1+ years)
• Must be able to work in a fast-pace environment and multi-task
• Detail oriented with good organizational skills
• Excellent teamwork with strong written/oral communication skills
• Work independently and troubleshoot technical problems
• Strong PC computer skills
• Microsoft Office proficiency, particularly design and use of spreadsheets

Additional Preferred Experience:

• Proficiency with scanning microscopes, such as Leica Aperio or Akoya (PerkinElmer) Vectra systems
• Proficiency with immunofluorescence using manual and/or automated platforms
• Experience with image management systems such as Indica Labs HALO Link or Leica eSlide Manager

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.