Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
An Associate position is immediately available in the Process Development group within the Therapeutic Products Program (TPP), a Fred Hutch Department supporting the development and manufacturing of novel biological molecules and innovative cell-based therapies for Phase I/II clinical testing. TPP includes facilities that provide assistance and service in process development, quality assurance (QA) quality control (QC) and production of biologics and cells according to Good Manufacturing Practice (GMP).
As a Process Development Associate, you will act as a key individual and team contributor within the lab with respect to coordinating activities, ensuring standardized procedures/data analysis, generating technical reports, and defining overall operational efficiency. This position interacts heavily with internal and external research scientists, GMP manufacturing staff, Analytical Development/Quality Control, Quality Assurance, and other scientific staff, as needed.
PLEASE NOTE: Funding for this term-limited position is available through October 2020. It is possible that during that time this individual may be considered for a permanent position, pending performance, should an opening become available.
This position involves the development and optimization of cell processing unit operations including cell selections from starting tissues, genetic modifications (viral transduction, electroporation, etc.), expansion conditions, media/cytokine optimization, cell harvests, cryopreservation, and freeze-thaw recovery. In addition, this position assists in the development of robust and repeatable analytical methods to characterize starting, in-process and final, formulated cellular products.
This position will also be involved in the phenotypic characterization of cell therapy products. Accordingly, strong skills in flow cytometry and functional cell-based assay design will be required to be successful in this role. Overall, development activities generate robust, scalable processes to support toxicology studies, transfer and product introduction into a GMP Cell Processing manufacturing facility, and IND generation to enable clinical trial initiation.