• Post-Doctoral Research Fellow, Immunotherapy

    Job ID
    12846
    Type
    Regular Full-Time
    Company
    Fred Hutchinson Cancer Research Center
    Location
    US-WA-Seattle
    Category
    Post-Doctoral Research Fellows and Associates
  • Overview

    Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

     

    The post-doctoral research fellow will work on independent and collaborative projects in Dr. Chapuis laboratory developing adoptive T cell immunotherapy for viral driven malignancies within the Program in Immunology and Clinical Research Division at Fred Hutchinson Cancer Research Center. The successful applicant will employ strategies for cloning T cell receptors (TCRs) and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The research fellow will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy.

     

    The Program in Immunology is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. The post-doctoral research fellow may also participate in the laboratory evaluation of ongoing clinical trials involving engineering of peripheral blood stem cell grafts for improved allogeneic hematopoietic stem cell transplantation outcomes, and in the development of future immunotherapy strategies. This is a full-time position with a salary based on the NIH scale and excellent benefits.

    Responsibilities

    • Study the function of human T cells
    • Molecular bench work with PCR, cloning, and vector design
    • Single cell RNA sequencing
    • Biostatistics and some basic programing skills
    • Cell Culture, cell sorting, flow cytometry, intercellular staining, and transfections
    • Validation through functional and killing assays.

    Qualifications

    • MD and/or a PhD in a biological science with a diverse knowledge of immunology
    • Dynamic and driven – engaging and encouraging in team environments
    • Willingness to write and apply for funding opportunities and abstracts
    • A strong research background
    • Proficient in molecular biology and cellular immunology technique and knowhow
    • Virology knowledge will assist in the AIM of this positon
    • Flow cytometry and cell signaling based assays
    • Experience in analysis of TCR signaling pathways and in lentiviral modification of T cells will be an advantage


    To be successful in this position, the post-doctoral research fellow must be highly motivated and driven to establish a career as a future independent investigator, will need to be able to work independently and play well with others.

    Our Commitment to Diversity

    We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

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