Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The research in the Bernstein lab has primarily focused on developmental aspects of normal and leukemic hematopoiesis with the specific goal of developing novel therapeutic modalities. In these efforts we have identified maturation linked cell surface antigens and have utilized this information for developing methods for targeted therapy of hematologic malignancies and for isolating and characterizing normal and malignant human hematopoietic stem cells. Current studies of normal hematopoiesis are aimed at determining the role of the Notch pathway to direct primitive hematopoietic precursors to commit to a particular maturational pathway or to self-renew. These efforts are currently being extended in studies of CAR T-cell self renewal and differentiation. Recent studies of leukemia focus on how cells in the marrow microenvironment protect the leukemic stem cells from therapy.
This position will be responsible for performing standard and investigative laboratory work in the Bernstein Lab, including performing bench-level experiments, operating analytical instruments, compiling and verifying the accuracy of research data as well as preparing charts, graphs and summaries.
The Research Technician I or II works under the direction of the Principal Investigator or higher-level laboratory personnel. This position will conduct experiments involving tissue culture with cell lines and primary cells, multi-color flow cytometry staining and analysis, and molecular biology methods, including PCR.