Fred Hutchinson Cancer Research Center, home to three Nobel laureates, is an independent, nonprofit research institute based in Seattle. Its interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Laboratories in the Basic Sciences Division investigate diverse areas of molecular, computational, cellular, developmental, evolutionary and structural biology, metabolism, virology and immunity. We utilize a broad range of experimental and computational approaches and model systems. Fred Hutch provides outstanding colleagues, a collegial atmosphere, and a wealth of resources, including core resources for imaging, proteomics, genomics, flow cytometry, high content screening, and small animal research. Frequent meetings and external seminars provide many opportunities for inter-lab collaborations.
The Cooper lab in the Basic Sciences Division at the Fred Hutchinson Cancer Research Center is seeking new postdoctoral fellows. The Cooper lab has a demonstrated history of high impact studies of signal transduction mechanisms associated with mammalian cell migration in cell culture and in vivo model systems. Potential projects include: investigating the interplay between tyrosine phosphorylation and ubiquitylation in cell migration; the in vivo roles of Cullin 5 ubiquitin ligase complexes; the non-adhesive functions of cadherins in cancer and development; and the dynamics of focal adhesion proteins. We are particularly interested in using live imaging of engineered cells to understand the sequence of events in cellular adhesions. Specifically, we want to know how focal adhesion turnover is regulated differently at the leading edge from under the cell body. What are the signals and how are they relayed to the adhesions? Candidates will be encouraged to build on these ideas and develop new directions for their research projects
Successful applicants will hold a PhD or MD and have extensive experience and interest in cell and/or developmental biology. In addition, applicants should have a 2+ years of experience working on projects in mammalian molecular, cellular or developmental biology. Hands on experience with cell imaging or murine developmental biology is desirable. The candidate should be enthusiastic, scientifically rigorous and inquisitive. Since the Cooper lab is small, the candidate will need the technical skills, confidence and drive it takes to start new directions. The candidate will be responsible for all aspects of their research project. They must be able to function independently and also be highly collaborative. Excellent written and verbal communication skills are essential.
To apply please submit your CV, a cover letter detailing your research interests and suitability for this position, and the names of at least two references.