• Lead Protein Scientist, Molecular Design and Therapeutics Core

    Job ID
    Regular Full-Time
    Fred Hutchinson Cancer Research Center
    Staff Scientist
  • Overview

    Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


    A highly qualified and motivated candidate is sought to join the leadership team under the laboratory of Jim Olson in the Clinical Research Division at the Fred Hutchinson Cancer Research Center. The focus of research conducted in our group is the discovery and advancement of novel therapeutic biologics using predictive assays, advanced efficacy models, and state of the art resources. The candidate will join a highly innovative program as the lead protein scientist with the goals of managing the protein science efforts to design, produce, purify, and characterize novel cysteine-dense peptides and other proteins utilizing a mammalian expression platform.


    The candidate is expected to lead the protein science efforts producing novel cysteine-dense peptides (CDPs), antibodies, antibody fragments, and other proteins with therapeutic activity for our internal discovery programs. Responsibilities will include protein and construct design of novel proteins, optimization of purification and characterization techniques for unique peptides and proteins, leadership of junior protein scientists, and interfacing with the automation group. In addition to protein modeling and design, routine techniques include protein production using a mammalian expression system, purification with ÄKTA chromatography systems, and application of biochemistry and biophysical assessments of protein folding, structure, and protein-protein interactions. This position will work closely with the automation, chemistry, and pharmacology teams within our group to achieve the goals of our internal programs. Further, the candidate will be the scientific point person for future collaborations with investigators at the Fred Hutch and other organizations in the local biotech community (both public and private). This position will require contributions at the individual level and as part of a larger team. It also requires the supervision of junior scientists. The Olson lab has a broad expertise in oncology, in vivo pharmacology, protein therapeutics, and clinical translation, and it provides a vibrant research environment for career advancement toward top-tier positions.



    • A PhD or equivalent, ideally in the areas of protein engineering, biochemistry, molecular biology, or a related field
    • A strong publication record
    • Expertise in structural biology, mammalian protein expression, and purification techniques


    • Experience with advanced biochemistry techniques to assess protein folding and protein-protein interactions
    • Experience with crystallography
    • Understanding of the drug discovery process in an industry setting
    • Management experience and a track record of successful collaborations

    Our Commitment to Diversity

    We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.


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