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A hallmark of many diseases and cancers is a dysfunctional cytoskeleton. A properly functioning cytoskeleton is needed for a wide variety of cellular events ranging from cell shape to cell signaling and migration/metastasis. The Parkhurst laboratory in the Basic Sciences Division at Fred Hutch uses multidisciplinary approaches to study these dynamic structural elements in various processes including wound repair and nuclear architecture/organization. Our goal is to understand the role of these elements in regulating normal developmental events and how this regulation goes awry in diseases/cancers, thereby providing new avenues for possible therapeutic targets or to enhance the effectiveness of existing treatment modalities.
Our current research efforts are divided among studies of: (1) Molecular and cellular mechanisms of single cell and multicellular (tissue) wound repair, and (2) Actin and microtubule cytoskeleton dynamics mediated by the Rho1 small GTPase and its effectors Wash, Capu, and Spire; and (3) Nuclear architecture and organization.
The research technician will primarily carry out an independent research project that involves cell biology, developmental genetics, and molecular biology. The technician will participate in lab meetings and journal clubs.
Other responsibilities include general lab maintenance (ordering, caring for Drosophila flies, fly media preparation), and other duties as needed. This is an ideal position for a recent graduate who wants to gain an intense research experience before pursuing graduate and/or medical school.