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The Green laboratory is focused on research developing new immunotherapeutic approaches to treat and ultimately eradicate multiple myeloma and lymphoma.
The post-doctoral research fellow will work on projects in the Green Lab primarily involving laboratory based research related to the evaluation of the proliferation, function, and trafficking of chimeric antigen receptor (CAR)-T cells to treat multiple myeloma and other B-cell malignancies. In addition, studies will be conducted to determine mechanisms of tumor resistance in patients and to evaluate processes through which the efficacy of the CAR-T cell constructs can be enhanced through rational combination with agents designed to augment the immune response.
The successful applicant will employ strategies such as functional T cell assays, multi-parametric flow cytometry, flow sorting, DNA extraction, analysis of sequencing data, isolation of CAR-T cells from the peripheral blood and BM of treated patients, isolation of RNA for scRNA-seq studies, quantitative PCR and bioinformatics analysis. The successful applicant will work closely with members of the Riddell lab on this project.
The position will involve supervision of one Full-Time Research Technician and oversee the day-to-day operations of research sample activities for multiple clinical research protocols.
Applicants will have a PhD in a biological science and/or a MD. The ideal candidate will have a research background in immunology with robust skills in molecular and cellular biology, including significant experience with flow cytometry, and experience with T cell functional assays, DNA and RNA extraction, molecular cloning, PCR and quantitative PCR. Desirable skills include bioinformatics analysis, scientific writing and presentations.
To be successful in this position, the post-doctoral research fellow must be highly motivated with a track record of productive research, exemplified by first author publication(s) and presentations, and willing to work in a highly collaborative, fast paced environment. This position is suited to someone who enjoys mastering new skills, multitasking and working in a team environment.
This is a full-time position with a salary based on the NIH scale and excellent benefits.