• Post-Doctoral Research Fellow, CAR-T Cell Immunotherapy for Hematologic Malignancy

    Job ID
    11852
    Type
    Regular Full-Time
    Company
    Fred Hutchinson Cancer Research Center
    Location
    US-WA-Seattle
    Category
    Post-Doctoral Research Fellows and Associates
  • Overview

    Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

    The Green laboratory is focused on research developing new immunotherapeutic approaches to treat and ultimately eradicate multiple myeloma and lymphoma.

    Responsibilities

    The post-doctoral research fellow will work on projects in the Green Lab primarily involving laboratory based research related to the evaluation of the proliferation, function, and trafficking of chimeric antigen receptor (CAR)-T cells to treat multiple myeloma and other B-cell malignancies. In addition, studies will be conducted to determine mechanisms of tumor resistance in patients and to evaluate processes through which the efficacy of the CAR-T cell constructs can be enhanced through rational combination with agents designed to augment the immune response.

     

    The successful applicant will employ strategies such as functional T cell assays, multi-parametric flow cytometry, flow sorting, DNA extraction, analysis of sequencing data, isolation of CAR-T cells from the peripheral blood and BM of treated patients, isolation of RNA for scRNA-seq studies, quantitative PCR and bioinformatics analysis. The successful applicant will work closely with members of the Riddell lab on this project.

     

    The position will involve supervision of one Full-Time Research Technician and oversee the day-to-day operations of research sample activities for multiple clinical research protocols.

    Qualifications

    Applicants will have a PhD in a biological science and/or a MD. The ideal candidate will have a research background in immunology with robust skills in molecular and cellular biology, including significant experience with flow cytometry, and experience with T cell functional assays, DNA and RNA extraction, molecular cloning, PCR and quantitative PCR. Desirable skills include bioinformatics analysis, scientific writing and presentations.

     

    To be successful in this position, the post-doctoral research fellow must be highly motivated with a track record of productive research, exemplified by first author publication(s) and presentations, and willing to work in a highly collaborative, fast paced environment. This position is suited to someone who enjoys mastering new skills, multitasking and working in a team environment.

     

    This is a full-time position with a salary based on the NIH scale and excellent benefits.

    Our Commitment to Diversity

    We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

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