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The Kublin Lab within the Vaccine and Infectious Disease Research Division is recruiting a postdoctoral fellow to work on a project investigating the role of the microbiome in vaccine-induced immunity. We are interested in how the gut microbial and immune systems communicate to shape immune responses to HIV vaccines and contribute to vaccine response heterogeneity. We will unravel mechanisms of immunity by perturbation of the immune system and the microbiome — the immune system via multiple adjuvanted immunization regimens in humans and murine models and the microbiome by gut microbial reconstitution in germ free murine models. Novel computational analyses integrating immune response, microbial relative abundance and metabolomics data will help guide vaccine and adjuvant design.
The candidate must be responsible, organized, and self-motivated, and able to efficiently manage time and experiments. The incumbent will help develop and apply the analytical tools necessary for interpreting the extensive clinical and murine microbiome and immunogenicity data, under the mentorship of the PI and computational biology faculty.