Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.
A hallmark of many diseases and cancers is the aberrant regulation of chromatin. Much like the cellular genome, viral genomes are compacted in virus particles with small basic molecules to maximize space and be poised for gene expression. Some DNA viruses use cellular histone proteins to compact their genomes whereas others use small basic molecules. The Avgousti lab in the Human Biology Division at Fred Hutch uses a multidisciplinary approach to uncover the mechanisms by which viruses hijack chromatin. Our goal is to advance basic understanding of viral manipulation of chromatin and reveal new aspects of chromatin biology thereby providing new avenues for possible therapeutic advances.
Our current research efforts are divided among studies of (1) a small basic protein from adenovirus, protein VII, that serves to compact its genome while wreaking havoc on the host genome, (2) host histones found on herpesvirus genomes during infection and how they can be exploited to block infection, and (3) using viral tools to block inflammation and cancer progression.
Additional information about research in the Avgousti lab can be found at:
Research technicians will be responsible for performing standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries.
Tech I: BA/BS in a scientific field required. Must have scientific knowledge in the area of study and basic laboratory skills. Independent research experience in addition to school lab experience is required.
Tech II: Intermediate level position requiring 2 years previous experience working in a laboratory and BA/BS. A Master's degree can substitute for 2 years of post-graduation lab experience.
A successful candidate will have scientific curiosity, a high level of self-motivation, the ability to take instruction and correction and to follow directions, good organizational skills, the ability to work and think independently and be able to make at least a two year commitment. The candidate have a track record of reliability and good verbal and written communication skills. Must be able to distinguish different intensities and hues of red color. This is an ideal position for a recent graduate who wants to gain an intense research experience before pursuing graduate school.