• Research Technician II - Jerome Lab, Viral Gene Editing

    Job ID
    11546
    Type
    Regular Full-Time
    Company
    Fred Hutchinson Cancer Research Center
    Location
    US-WA-Seattle
    Category
    Laboratory Research Sciences
  • Overview

    Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

     

    This is a mid-level research technician position that will work on potentially curative genetic therapies for persistent viral infections.  He/she will be responsible for performing animal studies to validate the potential of newly developed therapeutics in the lab. Responsibilities will include the production and characterization of in vivo grade therapeutics, performance of animal studies, and the analysis of experimental outcomes in blood and tissues.

     

    Candidate will work under the direction of the Principal Investigator and senior laboratory members, and work independently using discretion and judgment in carrying out experiments.

    Responsibilities

    1. Will be required to perform minor murine surgical procedures, including intramuscular, intravenous and intradermal injections, delivery of anesthesia by injection or inhalation, infection with live virus, shaving of fur, blood sampling, and also terminal euthanasia and removal of tissues. Processing of tissue samples for histology and nucleic acid extraction. May be required to assist in the maintenance of a murine colony, which will include breeding and genotyping.
    2. Assist in the production and purification of viral vector stocks required for animal studies including adeno associated virus, lentivirus and adenovirus.
    3. Must be able to work with supervisor and/or senior lab members in the design of experiments, and will be expected to be responsible for the progress of individual research projects, and to analyze data generated and modify techniques.
    4. Identify methodological problems in research protocols and implement modifications to optimize experimental results. Design experiments and develop protocols using techniques including tissue culture, flow cytometry, RNA and DNA extraction, PCR, standard molecular biology methods, tissue sectioning, histology, and immunohisto/cytochemistry.
    5. Prepare and present written and oral progress reports concerning studies including assembly, organization, and interpretation of data.
    6. Conduct literature reviews and background searches to assist in determining research methods.
    7. May perform statistical analyses and manage research database.
    8. Work with supervisor to understand project goals and hypotheses.
    9. Train other members of staff in techniques
    10. Assist in general maintenance of laboratory including stocking, ordering, maintaining stock and cell lines.
    11. The ideal candidate may work on multiple projects (often simultaneously) so should be highly organized, able to multi-task and have a proven ability to work well with others in a team environment.
    12. Other duties as required.

    Qualifications

    BA/BS or extensive laboratory experience (4+ years).  Intermediate level position requiring 2 years previous experience working in a laboratory and working with mice. The ideal applicant will have experience with studies performed in small animals including performing minor surgical procedures.  Experience with general methods in molecular biology, histology and tissue culture in a quality-conscious, high-throughput environment. Preference will be given to those with experience in virology. A high level of professionalism and respectful communication with animal health staff are required for this position.

    Our Commitment to Diversity

    We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.

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