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We are seeking to hire a staff scientist to manage and perform the day-to-day operations of the Fred Hutch Transgenic Mouse program. The main responsibility of the successful candidate will be to work with world-class researchers at Fred Hutch to generate genetically engineered gene-targeted/transgenic mice. The position will begin as soon as possible.
Work with research teams to develop gene targeting strategies;Work independently to perform the necessary techniques to generate gene targeted/transgenic mice, including the collection, microinjection, and reimplantation of fertilized eggs keep meticulous records and oversee the purchase and maintenance of necessary equipment and supplies; communicate with researchers on progress; troubleshoot technical difficulties; and implement and develop new techniques, particularly CRISPR/Cas9-mediated methods. In addition, the Staff Scientist will provide input into the long-term planning of the facility operation, and provide suggestions on how the facility can be run most efficiently. This position reports to the Associate Vice President of Shared Resources.
Applicants must possess a PhD degree in Molecular Biology or a related field, and have a minimum of 4 years of proven experience generating gene-targeted and/or transgenic mice. The successful candidate will be skilled in techniques necessary to generate transgenic and/or gene-targeted mice, including the collection, microinjection/electroporation, and reimplantation of fertilized mouse eggs. A proven ability to work independently to generate gene targeted/transgenic mice is required. Because the Transgenic Facility is shifting to CRISPR/Cas9-mediated techniques, and away from ES-cell technologies, experience with ES cell culture and blastocyst injection is not essential. However, experience working with RNA and with molecular biology techniques and CRISPR/Cas9-mediated gene targeting is a plus. Excellent communication skills and careful attention to detail are also required.