Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
Overview: Postdoctoral Research Fellow, Translational Mitochondrial Research in Cancer Prognosis, Therapeutics, and Genomics
We are currently recruiting a highly motivated PhD-level scientist to exploit and delineate the mechanisms underlying mtDNA mutagenesis to ultimately improve the survival of cancer patients, under the guidance of the following aims: 1) Test the hypothesis that mtDNA mutagenesis mediates apoptotic response, 2) Establish whether mtDNA mutation frequency is predictive of treatment response in breast cancer, and 3) Determine if mitochondrial-targeted cancer therapeutics promote apoptotic response.
The Bielas lab (http://research.fhcrc.org/bielas) is part of the Translational Research Program at the Fred Hutchinson Cancer Research Center. Our mission is to prevent disease, advance treatment, and increase patient survival. To this end, we pursue a broad-based methodological approach to elucidate the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the pathogenesis of cancer and age-related disease.
The majority of our projects set out to address long-standing intractable questions in mutation research, which have remained unanswered largely due to technical limitations. Thus, our first step typically involves the development of new methods and technologies to sensitively measure biological information. The application of these novel tools often reveals new insights into biology that exceed the scope of the hypothesis being tested, driving us down new and exciting pathways of discovery in pursuit of our overarching mission.
As such, while mutagenesis remains at the core of our research program, the focus of the laboratory continues to diversify and expand. Current and ongoing areas of interest include nuclear and mitochondrial genomics, DNA repair, transcriptomics, metabolomics, single cell biology, tumor immunology, cancer therapeutics and diagnostics.
PhD in a relevant biological field, with a strong background in molecular and cellular biology is required. Candidates should be able to demonstrate a track record of independent productive research, show willingness to help guide junior lab members, have strong organizational, written, and verbal skills, and possess the ability to work both independently and as part of a laboratory team.
Computational biology (programming) skills are highly desirable, as is experience in: cloning, transfection/infection of cells, PCR, and Southern/Northern/Western blotting, tissue culture, ddPCR, qPCR, mutational assays, FACs, live-cell imaging, single cell RNA sequencing (scRNA Seq), and Next Generation Sequencing (NGS).
Please include a CV, cover letter, and list of three references in your application.