Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The HIV Vaccine Trials Network (HVTN) is an international collaboration of scientists and educators searching for an effective and safe HIV vaccine. The HVTN’s mission is to fully characterize the safety, immunogenicity, and efficacy of HIV vaccine candidates with the goal of developing a safe, effective vaccine as rapidly as possible for prevention of HIV infections globally. Our organization conducts all phases of clinical trials, from evaluating experimental vaccines for safety and the ability to stimulate immune responses, to testing vaccine efficacy.
HIV Diagnostics in the context of vaccine and antibody mediated prevention trials is complex and requires significant oversight and expertise.
The HVTN employs four regional laboratories to perform the diagnostics for trials conducted in the U.S., Europe, Africa, and South America. These laboratories utilize the HVTN HIV Algorithm Workflow System (HAWS), which guides the laboratories through the diagnostics algorithms and creates reports for the clinics and independent adjudicators. All data from the HVTN diagnostic laboratories is uploaded to and analyzed by the HVTN Statistical Data Management Center. Clinical reports are distributed via a secure web-based system. Diagnostic testing includes multiple different serologic tests as well as assays for HIV RNA and DNA. Additional assays for low copy number RNA and viral outgrowth are currently under development and will be added to the diagnostic program in the future.
The HIV Diagnostics Project Manager will report to the HVTN Associate Director of Laboratory Operations. The incumbent will liaise directly with the P.I.s and laboratory managers of the four regional diagnostics laboratories for oversight of conduct of the HIV diagnostics as well as specimen management and data reporting. He/She will also assist clinical sites with any questions related to specimen collection or results reporting. He/She will monitor the HVTN HIV Diagnostic adjudication system and work with the adjudicators and programmers to address any problems in data upload or resolution of determinations.
PhD or Masters degree with appropriate experience may be considered.
Experience in HIV Diagnostic testing preferred.
Experience in a CLIA/CAP certified laboratory preferred.
Background in HIV virology and immunology preferred.