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The Silberstein Lab, a newly-established experimental hematopoiesis laboratory led by a physician-scientist is seeking to recruit a post-doctoral fellow or a trainee hematologist who is interested in pursuing laboratory-based research project. The laboratory is located at Fred Hutchinson Cancer Research Center in Seattle.
The main goal of the laboratory is to combine basic stem cell biology and clinically relevant murine models in order to develop new therapeutic approaches to promote HSC function in bone marrow failure and to enhance hematopoietic reconstitution post-transplant. We are particularly interested in using microenvironment-derived molecules as drugs or therapeutic targets, and have identified several novel niche factors using proximity-based single cell analysis as a discovery strategy (for details, please see Silberstein et al, Cell Stem Cell 2016, Goncalves, Silberstein et al, Cell 2016).
A successful candidate will be pursuing a study of extrinsic HSC regulators as potential therapeutics in preclinical models of myelodysplastic syndrome and Fanconi Anemia, which was recently funded by Leukemia and Lymphoma Society Translational Research Program grant. In parallel, they will be also involved in a project which investigates cellular and molecular mechanisms of HSC regulation by a newly-defined niche factor in normal and malignant hematopoiesis.
The candidate will be part of a Stem Cell and Gene Therapy Program at the Fred Hutch and interact closely with other laboratories within the Program which focus on gene therapy, early hematopoietic development and cellular reprogramming (Kiem, Adair, Bernstein, Hadland, Doulatov) and those within Integrated Immunotherapy Research Center (Dudakov, Turtle). There will be ample opportunities for data presentation and informal discussions. The candidate will be encouraged to develop research ideas and branch out into more independent projects. Mentorship and support for post-doctoral fellowship applications will be provided.
The candidate is expected to have a PhD and/or MD and a strong interest in stem cell research, expertise in molecular biology, flow cytometry, cell biology or imaging, and a commitment to basic/translational science in hematopoiesis. Previous experience of working with murine is not essential, but would be preferred. Proficiency in written and verbal English is required.
A cover letter explaining interest in the position and names and contacts of three references are required.