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Post-Doctoral Research Fellow, Viruses and Chromatin Biology

Post-Doctoral Research Fellow, Viruses and Chromatin Biology

Job ID 
10502
Type 
Regular Full-Time
Company 
Fred Hutchinson Cancer Research Center
Location 
US-WA-Seattle
Category 
Post-Doctoral Research Fellows and Associates

More information about this job

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

Responsibilities

The Avgousti lab at the Fred Hutchinson Cancer Research Center has an opening for a postdoctoral fellow. Our laboratory uses a multidisciplinary approach to investigate the mechanisms by which viruses hijack chromatin. Due to the major advancement in sequencing technologies and the expansion of the field of epigenetics, exploiting viruses to investigate chromatin biology has enormous potential. Our goal is to advance basic understanding of viral manipulation of chromatin and uncover new aspects of chromatin biology.

 

Much like the cellular genome, viral genomes are compacted in virus particles with small basic molecules to maximize space and be poised for gene expression. Some DNA viruses use cellular histone proteins to
 compact their genomes whereas others use small basic 
molecules. Adenoviruses encode their own 
histone-like protein, called protein VII, that forms a ‘beads 
on a string’ assembly with the viral genome. By examining protein VII in host chromatin, we discovered that protein VII sequesters the immune danger signal, HMGB1, in chromatin thereby dampening downstream inflammation (Avgousti et al, Nature 2016). This discovery sets the framework for deciphering how adenovirus manipulates host chromatin and more broadly how DNA viruses use histones or histone-like proteins for dual function: to compact their genomes and control host genomes.

Qualifications

We are looking for exceptional candidates with a recent PhD, a record of productive research (at least one first-author publication), with knowledge and experience in biochemistry and molecular biology. Virology experience would be preferred. Interested candidates should apply with a CV, a summary of research experience and interests, and contact information for three references.

Our Commitment to Diversity

We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We are proud to be an Equal Opportunity and VEVRAA Employer. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability, marital or veteran status, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at escmail@fredhutch.org or by calling 206-667-4700.